Cellular Components and Growth Factor Content of Platelet-Rich Plasma With a Customizable Commercial System

Abstract:
Background: Platelet-rich plasma (PRP) is an autologous orthobiologic treatment option for musculoskeletal conditions with favorable results in a limited number of high-quality clinical trials. Because different blood-processing methods result in PRP with varying cellular and growth factor content, it is critical that clinicians understand the content of the specific PRP being used in clinical practice. One adjustable system, the Angel System, has few independent laboratory reports on the specific composition of its PRP. The goal of this study was to quantify the cellular and growth factor composition of PRP produced by this system at its lowest hematocrit settings. Hypothesis: The authors hypothesized that the system would significantly concentrate platelets over baseline and, at the lowest hematocrit settings, would reduce leukocytes to produce leukocyte-poor PRP. Study Design: Descriptive laboratory study. Methods: Ten healthy male volunteers donated 150 mL of whole blood for processing. Three separate processing cycles were performed for each sample at the 0%, 1%, and 2% hematocrit settings. The resultant PRP from each cycle was sent for complete blood counts and enzyme-linked immunosorbent assay to quantify the following growth factors: platelet-derived growth factor (PDGF), basic fibroblast growth factor (bFGF), insulin-like growth factor-1 (IGF-1), and vascular endothelial growth factor (VEGF). Results: The system consistently concentrated platelets 5-fold over baseline, with no significant differences among settings. Leukocytes were concentrated at all settings, between 2 and 5 times over baseline. The 0% and 1% settings had significantly lower leukocyte concentrations than the 2% setting. Lymphocytes made up >89% of the leukocyte differential, while neutrophils represented <11% of the differential at each setting. There was a significant increase in PDGF and bFGF, a significant decrease in IGF-1, and no change in VEGF, with no difference among settings. Conclusion: The system consistently concentrated platelets 5 times but was unable to reduce leukocytes, therefore resulting in leukocyte-rich PRP at each setting tested. Leukocytes had a differential composition of >89% lymphocytes and <11% neutrophils. For all settings, PDGF and bFGF were concentrated; IGF-1 was reduced; and VEGF was not significantly different from baseline. Clinical Relevance: These data can serve to guide clinicians considering using this particular PRP system. It consistently yielded leukocyte-rich PRP with a lymphocyte-predominant/neutrophil-reduced profile. Further research is needed to better understand how to apply this specific PRP in clinical practice.
Author Listing: Michael Baria;W Kelton Vasileff;Meghan Miller;James Borchers;David C Flanigan;Sushmitha S Durgam
Volume: 47
Pages: 1216 - 1222
DOI: 10.1177/0363546519827947
Language: English
Journal: The American Journal of Sports Medicine

AMERICAN JOURNAL OF SPORTS MEDICINE

AM J SPORT MED

影响因子:4.2 是否综述期刊:是 是否OA:否 是否预警:不在预警名单内 发行时间:1976 ISSN:0363-5465 发刊频率:Bimonthly 收录数据库:SCIE/Scopus收录 出版国家/地区:UNITED STATES 出版社:SAGE Publications Inc.

期刊介绍

An invaluable resource for the orthopaedic sports medicine community, _The American Journal of Sports Medicine_ is a peer-reviewed scientific journal, first published in 1972. It is the official publication of the [American Orthopaedic Society for Sports Medicine (AOSSM)](http://www.sportsmed.org/)! The journal acts as an important forum for independent orthopaedic sports medicine research and education, allowing clinical practitioners the ability to make decisions based on sound scientific information.This journal is a must-read for: * Orthopaedic Surgeons and Specialists * Sports Medicine Physicians * Physiatrists * Athletic Trainers * Team Physicians * And Physical Therapists

《美国运动医学杂志》是骨科运动医学界的宝贵资源,是一本同行评议的科学杂志,于1972年首次出版。它是[美国运动医学骨科学会(AOSSM)]的官方出版物(http://www.sportsmed.org/)!该杂志作为独立的骨科运动医学研究和教育的重要论坛,使临床执业医师能够根据可靠的科学信息做出决策。* 矫形外科医生和专家 * 运动医学医生 * 理疗师 * 运动教练 * 队医 * 和物理治疗师

年发文量 332
国人发稿量 40
国人发文占比 12.05%
自引率 11.9%
平均录取率 很难
平均审稿周期 较快,2-4周
版面费 US$4000
偏重研究方向 医学-运动科学
期刊官网 http://ajs.sagepub.com/
投稿链接 -

质量指标占比

研究类文章占比 OA被引用占比 撤稿占比 出版后修正文章占比
93.43% 7.37% 0.00% 0.00%

相关指数

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期刊预警不是论文评价,更不是否定预警期刊发表的每项成果。《国际期刊预警名单(试行)》旨在提醒科研人员审慎选择成果发表平台、提示出版机构强化期刊质量管理。

预警期刊的识别采用定性与定量相结合的方法。通过专家咨询确立分析维度及评价指标,而后基于指标客观数据产生具体名单。

具体而言,就是通过综合评判期刊载文量、作者国际化程度、拒稿率、论文处理费(APC)、期刊超越指数、自引率、撤稿信息等,找出那些具备风险特征、具有潜在质量问题的学术期刊。最后,依据各刊数据差异,将预警级别分为高、中、低三档,风险指数依次减弱。

《国际期刊预警名单(试行)》确定原则是客观、审慎、开放。期刊分区表团队期待与科研界、学术出版机构一起,夯实科学精神,打造气正风清的学术诚信环境!真诚欢迎各界就预警名单的分析维度、使用方案、值得关切的期刊等提出建议!

预警情况 查看说明

时间 预警情况
2024年02月发布的2024版 不在预警名单中
2023年01月发布的2023版 不在预警名单中
2021年12月发布的2021版 不在预警名单中
2020年12月发布的2020版 不在预警名单中

JCR分区 WOS分区等级:Q1区

版本 按学科 分区
WOS期刊SCI分区
WOS期刊SCI分区是指SCI官方(Web of Science)为每个学科内的期刊按照IF数值排 序,将期刊按照四等分的方法划分的Q1-Q4等级,Q1代表质量最高,即常说的1区期刊。
(2021-2022年最新版)
ORTHOPEDICS Q1
SPORT SCIENCES Q1

关于2019年中科院分区升级版(试行)

分区表升级版(试行)旨在解决期刊学科体系划分与学科发展以及融合趋势的不相容问题。由于学科交叉在当代科研活动的趋势愈发显著,学科体系构建容易引发争议。为了打破学科体系给期刊评价带来的桎梏,“升级版方案”首先构建了论文层级的主题体系,然后分别计算每篇论文在所属主题的影响力,最后汇总各期刊每篇论文分值,得到“期刊超越指数”,作为分区依据。

分区表升级版(试行)的优势:一是论文层级的主题体系既能体现学科交叉特点,又可以精准揭示期刊载文的多学科性;二是采用“期刊超越指数”替代影响因子指标,解决了影响因子数学性质缺陷对评价结果的干扰。整体而言,分区表升级版(试行)突破了期刊评价中学科体系构建、评价指标选择等瓶颈问题,能够更为全面地揭示学术期刊的影响力,为科研评价“去四唯”提供解决思路。相关研究成果经过国际同行的认可,已经发表在科学计量学领域国际重要期刊。

《2019年中国科学院文献情报中心期刊分区表升级版(试行)》首次将社会科学引文数据库(SSCI)期刊纳入到分区评估中。升级版分区表(试行)设置了包括自然科学和社会科学在内的18个大类学科。基础版和升级版(试行)将过渡共存三年时间,推测在此期间各大高校和科研院所仍可能会以基础版为考核参考标准。 提示:中科院分区官方微信公众号“fenqubiao”仅提供基础版数据查询,暂无升级版数据,请注意区分。

中科院分区 查看说明

版本 大类学科 小类学科 Top期刊 综述期刊
医学
1区
ORTHOPEDICS
骨科
1区
SPORT SCIENCES
运动科学
1区
2021年12月
基础版
医学
2区
ORTHOPEDICS
骨科
1区
SPORT SCIENCES
运动科学
1区
2021年12月
升级版
医学
1区
ORTHOPEDICS
骨科
1区
SPORT SCIENCES
运动科学
1区
2020年12月
旧的升级版
医学
1区
ORTHOPEDICS
骨科
1区
SPORT SCIENCES
运动科学
1区
2022年12月
最新升级版
医学
1区
ORTHOPEDICS
骨科
1区
SPORT SCIENCES
运动科学
1区