Inflammation and cerebral small vessel disease: A systematic review

期刊介绍

As the average human life expectancy has increased, so too has the impact of ageing and age-related disease on our society. Ageing research is now the focus of thousands of laboratories that include leaders in the areas of genetics, molecular and cellular biology, biochemistry, and behaviour. Ageing Research Reviews (ARR) covers the trends in this field. It is designed to fill a large void, namely, a source for critical reviews and viewpoints on emerging findings on mechanisms of ageing and age-related disease. Rapid advances in understanding of mechanisms that control cellular proliferation, differentiation and survival are leading to new insight into the regulation of ageing. From telomerase to stem cells to energy and oxyradical metabolism, this is an exciting new era in the multidisciplinary field of ageing research. The cellular and molecular underpinnings of manipulations that extend lifespan, such as caloric restriction, are being identified and novel approaches for preventing age-related diseases are being developed. ARR publishes articles on focussed topics selected from the broad field of ageing research, with an emphasis on cellular and molecular mechanisms of the aging process and age-related diseases such as cancer, cardiovascular disease, diabetes and neurodegenerative disorders. Applications of basic ageing research to lifespan extension and disease prevention are also covered in this journal.

随着人类平均预期寿命的增加，老龄化和与年龄有关的疾病对我们社会的影响也在增加。衰老研究现在是数千个实验室的重点，其中包括遗传学、分子和细胞生物学、生物化学和行为学领域的领导者。老龄化研究评论（ARR）涵盖了这一领域的趋势。它的目的是填补一个巨大的空白，即对老龄化和与年龄有关的疾病的机制的新发现进行批判性审查和提出观点。对控制细胞增殖、分化和存活的机制的理解的快速进展导致对衰老调节的新认识。从端粒酶到干细胞再到能量和氧自由基代谢，这是衰老研究多学科领域令人兴奋的新时代。延长寿命的操作（如热量限制）的细胞和分子基础正在被确定，预防年龄相关疾病的新方法正在开发中。ARR发表的文章集中于从广泛的老龄化研究领域中选择的主题，重点是老龄化过程的细胞和分子机制以及与年龄相关的疾病，如癌症、心血管疾病、糖尿病和神经退行性疾病。这本杂志还介绍了基础老龄化研究在延长寿命和预防疾病方面的应用。

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JCR分区 WOS分区等级：Q1区

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