Identification and Modulation of Microenvironment Is Crucial for Effective Mesenchymal Stromal Cell Therapy in Acute Lung Injury.

Abstract:
Rationale: There are controversial reports on applications of mesenchymal stromal cells (MSCs) in patients with acute respiratory distress syndrome (ARDS). Objectives: We hypothesized that lung microenvironment was the main determinant of beneficial versus detrimental effects of MSCs during ARDS. Methods: Lung proteome was profiled in three models of injury induced by acid instillation and/or mechanical ventilation in mice. Human gene of glutathione peroxidase-1 was delivered before MSC administration; or MSCs carrying human gene of IL-10 or hepatocyte growth factor were administered after lung injury. An inhibitory cocktail against IL-6, fibronectin, and oxidative stress was used in in vitro studies using human small airway epithelial cells and human MSCs after exposure to plasma of patients with ARDS. Measurements and Main Results: Distinct proteomic profiles were observed in three lung injury models. Administration of MSCs protected lung from ventilator-induced injury, whereas it worsened acid-primed lung injuries associated with fibrotic development in lung environment that had high levels of IL-6 and fibronectin along with low antioxidant capacity. Correction of microenvironment with glutathione peroxidase-1, or treatment with MSCs carrying human gene of IL-10 or hepatocyte growth factor after acid-primed injury, reversed the detrimental effects of native MSCs. Proteomic profiles obtained in the mouse models were also similarly observed in human ARDS. Treatment with the inhibitory cocktail in samples of patients with ARDS retained protective effects of MSCs in small airway epithelial cells. Conclusions: MSCs can be beneficial or detrimental depending on microenvironment at the time of administration. Identification of potential beneficiaries seems to be crucial to guide MSC therapy in ARDS.
Author Listing: Diana Islam;Yongbo Huang;Vito Fanelli;Luisa Delsedime;Sulong Wu;Julie Khang;Bing Han;Alice Grassi;Manshu Li;Yonghao Xu;Alice Luo;Jianfeng Wu;Xiaoqing Liu;Montey McKillop;Jeffery Medin;Haibo Qiu;Nanshan Zhong;Mingyao Liu;John Laffey;Yimin Li;Haibo Zhang
Volume: 199 10
Pages: \n 1214-1224\n
DOI: 10.1164/rccm.201802-0356OC
Language: English
Journal: American journal of respiratory and critical care medicine

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

AM J RESP CRIT CARE

影响因子:19.3 是否综述期刊:是 是否OA:否 是否预警:不在预警名单内 发行时间:1994 ISSN:1073-449X 发刊频率:Semimonthly 收录数据库:SCIE/Scopus收录 出版国家/地区:UNITED STATES 出版社:American Thoracic Society

期刊介绍

The American Journal of Respiratory and Critical Care Medicine focuses on human biology and disease, as well as animal and in vitro studies that contribute to the understanding of pathophysiology and treatment of diseases that affect the respiratory system and critically ill patients.Papers that are solely or predominantly based in cell and molecular biology are published in the companion journal, the American Journal of Respiratory Cell and Molecular Biology. The Journal also seeks to publish clinical trials and outstanding review articles on areas of interest in several forms. The State-of-the-Art review is a treatise usually covering a broad field that brings bench research to the bedside. Shorter reviews are published as Critical Care Perspectives or Pulmonary Perspectives. These are generally focused on a more limited area and advance a concerted opinion about care for a specific process. Concise Clinical Reviews provide an evidence-based synthesis of the literature pertaining to topics of fundamental importance to the practice of pulmonary, critical care, and sleep medicine. Images providing advances or unusual contributions to the field are published as Images in Pulmonary, Critical Care, Sleep Medicine and the Sciences.

《美国呼吸和重症医学杂志》主要关注人类生物学和疾病,以及动物和体外研究,这些研究有助于理解病理生理学和影响呼吸系统和重症患者的疾病的治疗。单独或主要基于细胞和分子生物学的论文发表在姊妹杂志《美国呼吸细胞和分子生物学杂志》上。该杂志还寻求以多种形式发表临床试验和有关感兴趣领域的优秀综述文章。最新技术综述是一个论文,通常涵盖广泛的领域,使板凳研究的床边。较短的综述发表为《重症监护展望》或《肺部展望》。这些通常集中在一个更有限的领域,并提出了一个关于护理特定过程的一致意见。简明临床综述提供了一个循证综合的文献有关的主题的基本重要的实践肺,重症监护和睡眠医学。为该领域提供进步或不寻常贡献的图像被发表为《肺部、重症监护、睡眠医学和科学图像》。

年发文量 184
国人发稿量 14
国人发文占比 7.61%
自引率 5.7%
平均录取率 很难
平均审稿周期 一般,3-6周
版面费 -
偏重研究方向 医学-呼吸系统
期刊官网 http://ajrccm.atsjournals.org/
投稿链接 http://mc.manuscriptcentral.com/ajrccm

质量指标占比

研究类文章占比 OA被引用占比 撤稿占比 出版后修正文章占比
94.02% 25.57% 0.00% 6.90%

相关指数

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期刊预警不是论文评价,更不是否定预警期刊发表的每项成果。《国际期刊预警名单(试行)》旨在提醒科研人员审慎选择成果发表平台、提示出版机构强化期刊质量管理。

预警期刊的识别采用定性与定量相结合的方法。通过专家咨询确立分析维度及评价指标,而后基于指标客观数据产生具体名单。

具体而言,就是通过综合评判期刊载文量、作者国际化程度、拒稿率、论文处理费(APC)、期刊超越指数、自引率、撤稿信息等,找出那些具备风险特征、具有潜在质量问题的学术期刊。最后,依据各刊数据差异,将预警级别分为高、中、低三档,风险指数依次减弱。

《国际期刊预警名单(试行)》确定原则是客观、审慎、开放。期刊分区表团队期待与科研界、学术出版机构一起,夯实科学精神,打造气正风清的学术诚信环境!真诚欢迎各界就预警名单的分析维度、使用方案、值得关切的期刊等提出建议!

预警情况 查看说明

时间 预警情况
2024年02月发布的2024版 不在预警名单中
2023年01月发布的2023版 不在预警名单中
2021年12月发布的2021版 不在预警名单中
2020年12月发布的2020版 不在预警名单中

JCR分区 WOS分区等级:Q1区

版本 按学科 分区
WOS期刊SCI分区
WOS期刊SCI分区是指SCI官方(Web of Science)为每个学科内的期刊按照IF数值排 序,将期刊按照四等分的方法划分的Q1-Q4等级,Q1代表质量最高,即常说的1区期刊。
(2021-2022年最新版)
RESPIRATORY SYSTEM Q1
CRITICAL CARE MEDICINE Q1

关于2019年中科院分区升级版(试行)

分区表升级版(试行)旨在解决期刊学科体系划分与学科发展以及融合趋势的不相容问题。由于学科交叉在当代科研活动的趋势愈发显著,学科体系构建容易引发争议。为了打破学科体系给期刊评价带来的桎梏,“升级版方案”首先构建了论文层级的主题体系,然后分别计算每篇论文在所属主题的影响力,最后汇总各期刊每篇论文分值,得到“期刊超越指数”,作为分区依据。

分区表升级版(试行)的优势:一是论文层级的主题体系既能体现学科交叉特点,又可以精准揭示期刊载文的多学科性;二是采用“期刊超越指数”替代影响因子指标,解决了影响因子数学性质缺陷对评价结果的干扰。整体而言,分区表升级版(试行)突破了期刊评价中学科体系构建、评价指标选择等瓶颈问题,能够更为全面地揭示学术期刊的影响力,为科研评价“去四唯”提供解决思路。相关研究成果经过国际同行的认可,已经发表在科学计量学领域国际重要期刊。

《2019年中国科学院文献情报中心期刊分区表升级版(试行)》首次将社会科学引文数据库(SSCI)期刊纳入到分区评估中。升级版分区表(试行)设置了包括自然科学和社会科学在内的18个大类学科。基础版和升级版(试行)将过渡共存三年时间,推测在此期间各大高校和科研院所仍可能会以基础版为考核参考标准。 提示:中科院分区官方微信公众号“fenqubiao”仅提供基础版数据查询,暂无升级版数据,请注意区分。

中科院分区 查看说明

版本 大类学科 小类学科 Top期刊 综述期刊
医学
1区
RESPIRATORY SYSTEM
呼吸系统
1区
CRITICAL CARE MEDICINE
危重病医学
1区
2021年12月
基础版
医学
1区
RESPIRATORY SYSTEM
呼吸系统
1区
CRITICAL CARE MEDICINE
危重病医学
1区
2021年12月
升级版
医学
1区
RESPIRATORY SYSTEM
呼吸系统
1区
CRITICAL CARE MEDICINE
危重病医学
1区
2020年12月
旧的升级版
医学
1区
RESPIRATORY SYSTEM
呼吸系统
1区
CRITICAL CARE MEDICINE
危重病医学
1区
2022年12月
最新升级版
医学
1区
RESPIRATORY SYSTEM
呼吸系统
1区
CRITICAL CARE MEDICINE
危重病医学
1区