Facile Preparation of Carboxymethyl Cellulose/Cu Bio-Nanocomposite Hydrogels for Controlled Release of Ibuprofen

Abstract:
Abstract To develop a new drug delivery approach, carboxymethyl cellulose/Cu bio-nanocomposite hydrogels were successfully prepared in situ during the formation of Cu nanoparticles within swollen carboxymethyl cellulose hydrogels. The resulting hydrogels were examined by running various experimental procedures such as FT-IR, XRD, and SEM. XRD analysis confirmed the formation of Cu nanoparticles in the hydrogel matrix, while SEM micrographs showed that nanoparticles ranged from 36 to 69 nm within the same matrix. It was shown that increased Cu 2+ concentration led to increased number of Cu nanoparticles. The swelling behavior of the bio-nanocomposite hydrogels was studied at pH 2.1 and 7.4, and exhibited a pH-sensitive swelling ratio, compared with the neat carboxymethyl cellulose hydrogel. The antibacterial activity of the bio-nanocomposite hydrogels was examined and mechanisms involved in their synthesis were reported; the results showed an excellent antibacterial behavior of the bio-nanocomposite hydrogel. In vitro drug release tests were carried out to assess the effectiveness of this novel type of bio-nanocomposite as a controlled drug delivery system. Sustained and controlled drug releases were observed for Cu nanoparticles containing carboxymethyl cellulose, which increased with increases in Cu nanoparticle content. Lay Summary The objective of this study was to prepare and characterize a group of carboxymethyl cellulose hydrogels containing copper nanoparticles. Novel carboxymethyl cellulose/Cu nanocomposite hydrogels were successfully prepared by in situ formation of Cu nanoparticles in the carboxymethyl cellulose hydrogel matrix. The effect of the concentration of the Cu nanoparticles on the swelling and drug release behavior and antibacterial activity for the Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus bacteria was investigated.
Author Listing： Iman Gholamali
Volume： 6
Pages： 115-124
DOI： 10.1007/s40883-019-00133-2
Language： English
Journal： Regenerative Engineering and Translational Medicine

Regenerative Engineering and Translational Medicine

REGEN ENG TRANSL MED

影响因子：2.2 是否综述期刊：否 是否OA：否 是否预警：不在预警名单内 发行时间：- ISSN：2364-4133 发刊频率：4 issues per year 收录数据库：ESCI/Scopus收录 出版国家/地区：- 出版社：Springer Nature

期刊介绍

Regenerative Engineering is an international journal covering convergence of the disciplines of tissue engineering, advanced materials science, stem cell research, the physical sciences, and areas of developmental biology. This convergence brings exciting opportunities to translate bench-top research into bedside methods, allowing the possibility of moving beyond maintaining or repairing tissues to regenerating them. The journal encourages both top-down engineering approaches and bottom-up strategies integrating materials science with stem cell research and developmental biology. Convergence papers on instructive biomaterials, stimuli-responsive biomaterials, micro- and nano-patterning for regenerative engineering, elastomeric biomaterials, hydrogels for tissue engineering, and rapid prototyping and bioprinting approaches are particularly welcome. The journal provides a premier, single-blind peer-reviewed forum for the publication of original papers, authoritative reviews, rapid communications, news and views, and opinion papers addressing the most important issues and efforts toward successfully regenerating complex human tissues and organs. All research articles feature a lay abstract highlighting the relevance and future impact for patients, government and other health officials, and members of the general public. Bridging the gap between the lab and the clinic, the journal also serves as a dedicated platform for showcasing translational research that brings basic scientific research and discoveries into clinical methods and therapies, contributing to the improvement of human health care.Topics covered in Regenerative Engineering and Translational Medicine include:Advanced materials science for regenerative and biomedical applicationsStem cells for tissue regenerationDrug delivery for tissue regenerationNanomaterials and nanobiotechnology for tissue regenerationStudies combining tissue engineering/regeneration with developmental biologyConvergence research in pre-clinical and clinical phases

《再生工程》是一本国际性期刊，涵盖组织工程、先进材料科学、干细胞研究、物理科学和发育生物学等学科。这种融合带来了将实验室研究转化为临床方法的令人兴奋的机会，使其有可能超越组织的维护或修复而进行再生。该杂志鼓励自上而下的工程方法和自下而上的战略，整合材料科学与干细胞研究和发育生物学。特别欢迎关于指导性生物材料、刺激响应性生物材料、再生工程的微米和纳米图案、弹性生物材料、组织工程的水凝胶以及快速原型和生物打印方法的论文。该杂志提供了一个主要的、单盲同行评审论坛，用于发表原创论文、权威评论、快速通信、新闻和观点以及意见论文，讨论最重要的问题和成功再生复杂人体组织和器官的努力。所有研究文章都有一个简明摘要，强调了对患者、政府和其他卫生官员以及普通公众的相关性和未来影响。《再生工程》和《转化医学》的主题包括：用于再生和生物医学应用的先进材料科学用于组织再生的干细胞用于组织再生的药物输送用于组织再生的纳米材料和纳米生物技术用于组织再生的纳米材料和纳米生物技术将组织工程/再生与发育生物学相结合的研究临床前和临床阶段的融合研究

年发文量 38
国人发稿量 -
国人发文占比 0%
自引率 4.5%
平均录取率 -
平均审稿周期 -
版面费 US$2890
偏重研究方向 ENGINEERING, BIOMEDICAL-
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52.63% 13.64% - -

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