NK cell function is impaired during long-duration spaceflight.

Abstract:
Maintaining astronaut health during space travel is paramount for further human exploration of the solar system beyond Earth s orbit. Of concern are potential dysregulations in immunity, which could increase the likelihood of cancer and latent viral reactivation. Natural killer (NK) cells are critical effectors of the innate immune system, and their function and phenotype are important to immunosurveillance of nascent tumors and latent viral infections. We compared changes in NK cell phenotype and function in eight crew members who completed an ~6-mo mission to the International Space Station (ISS) with healthy controls who remained on Earth. Assessments were made before (180 and 60 days before launch), during [flight day + 90 days (FD+90) and 1 day before return (R-1)], and after the mission (at R+0, R+18, R+33, and R+66). These samples, plus an additional in-flight sample (FD+180), were collected from a crew member who spent 340 days (~1 yr) on the ISS. NK cell cytotoxic activity (NKCA) against K562 leukemia targets in vitro was reduced by ~50% at FD+90 in ISS crew but not controls. This decrease was more pronounced in rookie compared with veteran crew members. The ~1-yr mission crew member did not show declines in NKCA against K562 until late in the mission (R-1 and R+0). NK cell numbers, expression of activating and inhibitory receptors, target cell binding, and expression and degranulation of perforin and granzyme B were unaltered with spaceflight. Similarly, when we exposed an immortalized NK cell line (NK-92) to sera collected at different mission time points (before, during, and after flight), there was no effect on NKCA. This is the first study to report impaired NK cell function during long-duration space travel. Countermeasures may be needed to mitigate immune system impairment in exploration class mission crew during long-duration spaceflight missions. NEW & NOTEWORTHY Immune system impairment may inhibit future human space exploration missions to Mars. Natural killer (NK) cells are key components of immunity and vital for tumor surveillance and the prevention of latent virus reactivation. We report that NK cell function is impaired in astronauts during an ~6-mo orbital space mission compared with preflight levels and ground-based controls. Declines in NK cell function were more marked in first-time rookie fliers. Countermeasures are needed to preserve NK cell-mediated immunity during spaceflight.
Author Listing: Austin B Bigley;Nadia H Agha;Forrest L Baker;Guillaume Spielmann;Hawley E Kunz;Preteesh L Mylabathula;Bridgette V Rooney;Mitzi S Laughlin;Satish K Mehta;Duane L Pierson;Brian E Crucian;Richard J Simpson
Volume: 126 4
Pages: \n 842-853\n
DOI: 10.1152/japplphysiol.00761.2018
Language: English
Journal: Journal of applied physiology

JOURNAL OF APPLIED PHYSIOLOGY

J APPL PHYSIOL

影响因子:3.3 是否综述期刊:否 是否OA:否 是否预警:不在预警名单内 发行时间:1985 ISSN:8750-7587 发刊频率:Monthly 收录数据库:SCIE/Scopus收录 出版国家/地区:UNITED STATES 出版社:American Physiological Society

期刊介绍

The Journal of Applied Physiology publishes the highest quality original research and reviews that examine novel adaptive and integrative physiological mechanisms in humans and animals that advance the field. The journal encourages the submission of manuscripts that examine the acute and adaptive responses of various organs, tissues, cells and/or molecular pathways to environmental, physiological and/or pathophysiological stressors. As an applied physiology journal, topics of interest are not limited to a particular organ system. The journal, therefore, considers a wide array of integrative and translational research topics examining the mechanisms involved in disease processes and mitigation strategies, as well as the promotion of health and well-being throughout the lifespan. Priority is given to manuscripts that provide mechanistic insight deemed to exert an impact on the field.

《应用生理学杂志》发表了最高质量的原创研究和评论,探讨了人类和动物中新的适应性和整合性生理机制,推动了该领域的发展。该杂志鼓励投稿,研究各种器官、组织、细胞和/或分子途径对环境、生理和/或病理生理应激源的急性和适应性反应。作为应用生理学杂志,感兴趣的主题不限于特定的器官系统。因此,该杂志考虑了一系列广泛的综合和转化研究主题,研究疾病过程和缓解策略中涉及的机制,以及促进整个生命周期的健康和福祉。优先考虑那些提供了被认为对该领域产生影响的机械论见解的手稿。

年发文量 276
国人发稿量 15
国人发文占比 5.43%
自引率 6.1%
平均录取率 很难
平均审稿周期 较快,2-4周
版面费 -
偏重研究方向 医学-生理学
期刊官网 http://jap.physiology.org/
投稿链接 http://jappl.msubmit.net/cgi-bin/main.plex

质量指标占比

研究类文章占比 OA被引用占比 撤稿占比 出版后修正文章占比
94.93% 8.21% 0.00% 1.49%

相关指数

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期刊预警不是论文评价,更不是否定预警期刊发表的每项成果。《国际期刊预警名单(试行)》旨在提醒科研人员审慎选择成果发表平台、提示出版机构强化期刊质量管理。

预警期刊的识别采用定性与定量相结合的方法。通过专家咨询确立分析维度及评价指标,而后基于指标客观数据产生具体名单。

具体而言,就是通过综合评判期刊载文量、作者国际化程度、拒稿率、论文处理费(APC)、期刊超越指数、自引率、撤稿信息等,找出那些具备风险特征、具有潜在质量问题的学术期刊。最后,依据各刊数据差异,将预警级别分为高、中、低三档,风险指数依次减弱。

《国际期刊预警名单(试行)》确定原则是客观、审慎、开放。期刊分区表团队期待与科研界、学术出版机构一起,夯实科学精神,打造气正风清的学术诚信环境!真诚欢迎各界就预警名单的分析维度、使用方案、值得关切的期刊等提出建议!

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时间 预警情况
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2023年01月发布的2023版 不在预警名单中
2021年12月发布的2021版 不在预警名单中
2020年12月发布的2020版 不在预警名单中

JCR分区 WOS分区等级:Q1区

版本 按学科 分区
WOS期刊SCI分区
WOS期刊SCI分区是指SCI官方(Web of Science)为每个学科内的期刊按照IF数值排 序,将期刊按照四等分的方法划分的Q1-Q4等级,Q1代表质量最高,即常说的1区期刊。
(2021-2022年最新版)
PHYSIOLOGY Q1
SPORT SCIENCES Q1

关于2019年中科院分区升级版(试行)

分区表升级版(试行)旨在解决期刊学科体系划分与学科发展以及融合趋势的不相容问题。由于学科交叉在当代科研活动的趋势愈发显著,学科体系构建容易引发争议。为了打破学科体系给期刊评价带来的桎梏,“升级版方案”首先构建了论文层级的主题体系,然后分别计算每篇论文在所属主题的影响力,最后汇总各期刊每篇论文分值,得到“期刊超越指数”,作为分区依据。

分区表升级版(试行)的优势:一是论文层级的主题体系既能体现学科交叉特点,又可以精准揭示期刊载文的多学科性;二是采用“期刊超越指数”替代影响因子指标,解决了影响因子数学性质缺陷对评价结果的干扰。整体而言,分区表升级版(试行)突破了期刊评价中学科体系构建、评价指标选择等瓶颈问题,能够更为全面地揭示学术期刊的影响力,为科研评价“去四唯”提供解决思路。相关研究成果经过国际同行的认可,已经发表在科学计量学领域国际重要期刊。

《2019年中国科学院文献情报中心期刊分区表升级版(试行)》首次将社会科学引文数据库(SSCI)期刊纳入到分区评估中。升级版分区表(试行)设置了包括自然科学和社会科学在内的18个大类学科。基础版和升级版(试行)将过渡共存三年时间,推测在此期间各大高校和科研院所仍可能会以基础版为考核参考标准。 提示:中科院分区官方微信公众号“fenqubiao”仅提供基础版数据查询,暂无升级版数据,请注意区分。

中科院分区 查看说明

版本 大类学科 小类学科 Top期刊 综述期刊
医学
2区
PHYSIOLOGY
生理学
2区
SPORT SCIENCES
运动科学
3区
2021年12月
基础版
医学
3区
PHYSIOLOGY
生理学
3区
SPORT SCIENCES
运动科学
2区
2021年12月
升级版
医学
3区
PHYSIOLOGY
生理学
2区
SPORT SCIENCES
运动科学
3区
2020年12月
旧的升级版
医学
3区
PHYSIOLOGY
生理学
2区
SPORT SCIENCES
运动科学
3区
2022年12月
最新升级版
医学
3区
PHYSIOLOGY
生理学
2区
SPORT SCIENCES
运动科学
3区