Melanocytoma-acanthoma in a Dog

Abstract:
Background : Melanocytic neoplasms are skin tumors that often occur in dogs.\xa0 However, melanocytoma-acanthoma, also called melanoacanthoma, is a benign melanocytic neoplasm rarely reported in this species, which has been described only three times in the veterinary literature. Briefly, this tumor is characterized by a single, painless, darkly pigmented and firm cutaneous papule or nodule. Histologically, it is composed of mixed populations of well-differentiated melanocytes and keratinocytes, unlike traditional melanocytic tumors (melanoma and melanocytoma). These cells are arranged in lobules surrounded by collagenous stroma. Melanocytes are large epithelioid cells containing varying amounts of melanin. Keratinocytes form anastomosing trabeculae with peripheral palisading, and small cysts containing amorphous or laminated keratin. The definitive diagnosis of melanocytoma-acanthoma is based on histopathological findings. This report describes a case of melanocytoma-acanthoma in a dog in Brazil. Case : A 9-year-old female miniature Schnauzer dog was examined at the Veterinary Hospital of the Federal University of Santa Maria, where a single, firm, pigmented papule was found in the auricle. The lesion had started 15 days earlier. Hematological tests and serum biochemistry profile were normal. An excisional biopsy of the papule was surgically removed and subjected to histopathological examination. The tissue was fixed in 10% neutral buffered formalin, processed routinely and embedded in paraffin wax. Sections were stained with hematoxylin and eosin (HE). A histopathological examination revealed a nonencapsulated, well-defined, extensive, densely cellular proliferation located in dermis. This proliferation was composed of lobules and nests of well-differentiated stratified squamous epithelium closely associated with neoplastic melanocytes, surrounded by thin bundles of fibrous stroma. A diagnosis of melanocytoma-acanthoma was established based on these histological features. Discussion : The first description of melanocytoma-acanthoma in humans was as melano-epithelioma, classified into subtypes I and II. Both subtypes are benign neoplasms composed of well-differentiated melanocytes and keratinocytes, which are distinguished from one another based on the amount and distribution of melanocytes. Type I melano-epithelioma is characterized by proliferative lobules of melanocytes and keratinocytes, including melanocytes scattered diffusely among keratinocytes. Type II melano-epithelioma involves only the proliferation of keratinocytes, while melanocytes are limited to the basal layer of keratinocyte lobules. To clarify this condition, some authors use the term “melanoacanthoma” to indicate the above-described type I melano-epithelioma, and seborrheic keratosis to indicate type II melano-epithelioma. However, other authors use the term melanoacanthoma to denote the two conditions (types I and II melano-epithelioma). On the other hand, veterinary medicine does not recognize subtypes, instead using the term melanocytoma-acanthoma, and more recently, melanoacanthoma, to denote this cutaneous neoplasm. Melanocytoma-acanthoma in dogs was first reported in Spain, and involved a 2-year-old German shepherd dog. Later, two other cases were described in adult mixed-breed dogs, one in South Korea and the other in Libya. This is the first report of melanocytoma-acanthoma in a dog in Brazil. The gross and histopathological appearance of this case matches that described in the previous cases (a single, well-defined, pigmented cutaneous papule or nodule). Histologically, the differential diagnosis for melanocytoma-acanthoma includes melanoma, melanocytoma, trichoepithelioma, and sebaceous epithelioma.
Author Listing： Renata D. Mazaro;Douglas Miotto Lorensetti;Alana Pivoto Herbichi;Rafael A. Fighera
Volume： 47
Pages： None
DOI： 10.22456/1679-9216.90940
Language： English
Journal： Acta Scientiae Veterinariae

Acta Scientiae Veterinariae

ACTA SCI VET

影响因子：0.2 是否综述期刊：否 是否OA：否 是否预警：不在预警名单内 发行时间：2002 ISSN：1678-0345 发刊频率：Tri-annual 收录数据库：SCIE/Scopus收录 出版国家/地区：BRAZIL 出版社：Universidade Federal do Rio Grande do Sul

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ASV is concerned with papers dealing with all aspects of disease prevention, clinical and internal medicine, pathology, surgery, epidemiology, immunology, diagnostic and therapeutic procedures, in addition to fundamental research in physiology, biochemistry, immunochemistry, genetics, cell and molecular biology applied to the veterinary field and as an interface with public health.The submission of a manuscript implies that the same work has not been published and is not under consideration for publication elsewhere. The manuscripts should be first submitted online to the Editor. There are no page charges, only a submission fee.

ASV 关注 的 论文 涉及 疾病 预防 、 临床 和 内科 、 病理 学 、 外科 、 流行 病学 、 免疫 学 、 诊断 和 治疗 程序 的 各个 方面 ，细胞 和 分子 生物 学 应用 于 兽医 领域 并 作为 公共 卫生 的 接口 。提交 手稿 意味 着 同一 作品 尚未 出版 ， 也 未 考虑 在 其他 地方 出版 。稿件 应 首先 在线 提交 给 编辑 。没有 页面 费用 ， 只有 提交 费 。

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