ACTA VETERINARIA BRNO 投稿命中率-刊鹿论文编译

The effect of Ferulago angulata (Schelchet) Boiss on blood glucose levels and suppression of diabetes in rats

Abstract:

Diabetes mellitus is a metabolic disease characterized by elevated blood glucose levels. Medicinal plant Ferulago angulata has anti-oxidant properties. The aim of the present research was to evaluate the effect of a hydroalcoholic extract of F. angulata on the blood glucose level and liver enzyme activity in diabetic male rats. Forty-eight male rats were randomly divided into eight groups, including normal and diabetic groups. Diabetes was induced by a single intraperitoneal injection of streptozotocin at 40 mg·kg-1 body weight. Rats were treated with an intraperitoneal injection of the extract for three weeks. At the end of the experimental period, fasting blood samples were collected, and blood glucose and liver enzyme activity were measured. This study demonstrated that serum glucose levels in diabetic groups treated with F. angulata were significantly lower than those in diabetic rats (P < 0.001). Alanine aminotransferase levels in diabetic rats treated with F. angulata were significantly decreased compared to diabetic rats (P < 0.001). Aspartate aminotransferase levels in diabetic rats treated with 200 and 400 mg·kg-1 F. angulata were significantly decreased compared to diabetic rats (P < 0.001). No significant differences were observed in the serum levels of blood glucose and liver enzymes in the normal group treated with different doses of the extract. These results show that the hydroalcoholic extract of F. angulata might be effective in the treatment of diabetes and consequently alleviate the liver damage caused by streptozotocin-induced diabetes mellitus. This effect might be due to the presence of flavonoids and their antioxidant features. Diabetic rat, herbal extract, liver enzymes, streptozotocin Diabetes mellitus is a systemic disease of great significance. Compared to other diseases, diabetes is a disease of high prevalence. Type 2 diabetes mellitus is much more prevalent than type 1 diabetes. Diabetes-induced hyperglycaemia and hyperlipidaemia can cause many structural and metabolic disorders in different body organs including the liver (Li et al. 2004). Liver is a key organ involved in glucose metabolism and energy homeostasis. A large amount of carbohydrates absorbed from the gastrointestinal tract undergoes hepatic processing and subsequent storage as glycogen or metabolism into amino acids or fatty acids. There is a very strong correlation between diabetes and liver disease (Friedman et al. 2003). The aminotransferases are the most frequently utilized and specific indicators of hepatocellular necrosis. Alanine aminotransferase (ALT) is primarily localized to the liver, but the aspartate aminotransferase (AST) is present in a wide variety of tissues like the heart, skeletal muscle, kidney, brain and liver (Li et al. 2004). Many studies have indicated that oxidative stress is also one of the major routes of pathophysiological condition during diabetes mellitus. Persistent hyperglycaemia causes increased production of free radicals, especially reactive oxygen species (ROS), in tissues from glucose auto-oxidation and protein glycosylation. Several reports have suggested that increased free radical-mediated oxidative stress is involved in diabetic complications (McGarry 2002). Use of medicinal plants in medicine is increasing because of their widespread use and curing various diseases ACTA VET. BRNO 2019, 88: 349–354; https://doi.org/10.2754/avb201988030349 Address for correspondence: Somayeh Bohlouli Department of Veterinary Medicine, College of Agriculture Kermanshah Branch, Islamic Azad University Kermanshah, Iran Phone: +989113232385 Email: sbohloli@yahoo.com http://actavet.vfu.cz/ (Soto et al. 2003). Ferulago angulata, locally called “chavir”, belongs to the Apiaceae family and is a natural and traditional plant in western parts of Iran (Khan Ahmadi et al. 2011). It also grows in other countries, including Turkey, Greece, Serbia and Macedonia (Baser 2002). The hydro-alcoholic extract of F. angulata contains phenolic compounds and has antioxidant and anti-diabetic effects. It is considered an important herb in Iran. Ferulago angulata extract is composed predominantly of ferulagone, β-hydroxy-13epi-manoyl oxide, α-Pinene, 2,5-dimethoxy-p-cymene, p-Cymene, methyl carvacrol, transchrysanthenyl acetate, γterpinene, (Z)-β-ocimene, α-pinene, myrcene, terpinolene, 2,4,5-Trimethylbenzaldehyde and α-phellandrene (Sodeifian et al. 2011). Phenolic compounds, owing to their antioxidant activity, are capable of inhibiting free radicals; thus, they can be effective in preventing many diseases like cancer, cardiovascular and nervous diseases (Hosseini et al. 2012). Ferulago angulata is a strong antioxidant and can be used instead of synthetic antioxidants in the food industry (Sadeghi et al. 2016a). The plant is an effective antioxidant that can stabilize sunflower oil and soybean oil during storage (Sadeghi et al. 2016b). Administration of F. angulata extract has shown a positive effect on the immunological indices and immune system activity in rainbow trout (Oncorhynchus mykiss) fingerlings (Bohlouli and Sadeghi 2016). Ferulago angulata has been found to have aphrodisiac properties, and has been used as sedative, tonic, remedy of digestive pains and haemorrhoids, etc. Since a long time ago, Ferulago species have been good for ulcers, snake bites, spleen and headache (Zare Shahneh et al. 2013). This study was carried out to evaluate the effects of F. angulata (Schelcht) Boiss on blood glucose levels and liver enzymes of male rats. Materials and Methods Preparation of a hydro-alcoholic extract of F. angulata Ferulago angulata plant used in this study was obtained from the Dallaho Mountains of Kermanshah in western Iran in late spring. The plant was identified by the herbarium of the Islamic Azad University, Kermanshah Branch. The fresh plant (stem, leaf and flower) was dried and powdered. Two hundred g of powdered plant were kept in 500 ml of 70% ethanol for 48 h at room temperature. Ferulago angulata powder and ethanol mix were stirred occasionally, and then alcohol and powder mix were finely filtered to obtain its extract. The obtained extract was distilled in vacuum to evaporate its alcohol completely. The soaked plant was extracted by the percolation method, removed from the percolator, and filtered by the Whatman filter paper grade 4 (20–25 μm). It was dried under reduced pressure at 37 °C with a rotator evaporator (Bohlouli and Sadeghi 2016). The F. angulata extract is predominantly composed of ferulagone, α-Pinene, 2, 5-dimethoxy-p-cymene, p-Cymene, γterpinene, (Z)-β-ocimene, α-pinene, myrcene, and terpinolene.

Author Listing： Rahil Parsamehr;Somayeh Bohlouli

Volume： 88

Pages： 349-354

DOI： 10.2754/avb201988030349

Language： English

Journal： Acta Veterinaria Brno

ACTA VETERINARIA BRNO

ACTA VET BRNO

影响因子：0.6

是否综述期刊：否

是否OA：是

是否预警：不在预警名单内

发行时间：1969

ISSN：0001-7213

发刊频率：Quarterly

收录数据库：SCIE/Scopus收录

出版国家/地区：CZECH REPUBLIC

出版社：University of Veterinary and Pharmaceutical Sciences

期刊介绍

ACTA VETERINARIA BRNO is a scientific journal of the University of Veterinary and Pharmaceutical Sciences in Brno, Czech Republic.The scientific journal Acta Veterinaria Brno is dedicated to the publication of original research findings and clinical observations in veterinary and biomedical sciences. Original scientific research articles reporting new and substantial contribution to veterinary science and original methods that have not been submitted for publication elsewhere are considered for publication. A written statement to this effect should accompany the manuscript, along with approval for publication by the author´s head of department. The authors bear full responsibility for the contents of their contribution. Book reviews are published, too.

《布尔诺兽医学报》（Acta Veterinaria Brno）是捷克共和国布尔诺兽医和制药科学大学的科学期刊，专门发表兽医和生物医学科学的原创研究成果和临床观察。报告对兽医科学有新的和实质性贡献的原始科学研究文章以及尚未在其他地方提交发表的原始方法将被考虑发表。手稿应附有一份书面声明，沿着附有作者所在部门负责人的出版批准。作者对其稿件内容承担全部责任。书评也出版了。

年发文量	53
国人发稿量	-
国人发文占比	0%
自引率	33.3%
平均录取率	容易
平均审稿周期	较慢,18-36周
版面费	-
偏重研究方向	农林科学-兽医学
期刊官网	http://actavet.vfu.cz/
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