Antagonistic Effects Of Baicalin On Mycoplasma gallisepticum-Induced Inflammation And Apoptosis By Restoring Energy Metabolism In The Chicken Lungs

Abstract:
Background Baicalin possesses potential anti-inflammatory, anti-tumor and anti-oxidant activities. In the present study, we attempted to investigate the preventive effects of baicalin against Mycoplasma gallisepticum (MG)-induced inflammation, apoptosis and energy metabolism dysfunction in chicken lungs. Methods Experimental chickens were randomly divided into 1) control group, 2) MG infection group, 3) MG-infected group treated with baicalin at a dose of 450 mg/kg and 4) baicalin alone treated group (450 mg/kg). After 7 days of post-treatment, serum and lung tissues were collected for different experimental analyses. The hallmarks of inflammation, apoptosis and energy metabolism dysfunction were detected by histological and ultrastructural examination, qRT-PCR, Western blotting and terminal deoxynucleotidyl transferase-mediated dUTP nick endlabeling (TUNEL) assay. Results The level of serum inflammatory markers were increased with MG infection. Histological and ultrastructural analysis showed excessive inflammatory cells infiltrates, alveolar wall thickening, hemorrhages, mitochondrial and nuclear damage, including mitochondrial swelling and condensation of DNA in the lungs of chickens infected with MG. TUNEL assay positive-stained nuclei were significantly increased in MG infection group. In addition, the mRNA and protein expression level of energy metabolism-related genes and ATPase activities were significantly reduced. Meanwhile, MG-induced morphological and ultrastructural changes were partially disappeared with baicalin-treatment, and the level of serum inflammatory markers were significantly reduced. It has been noted that baicalin significantly attenuated MG-induced inflammation and apoptosis in the chicken lungs through the suppression of nuclear factor-kappa B and reduced extensive positive-stained apoptotic nuclei. More importantly, ATPase activities and mRNA and protein expression level of energy metabolism-related genes were significantly improved with baicalin-treatment in the lungs of chickens infected with MG. Conclusion Conclusively, it has been suggested from these results that baicalin-treatment efficiently prevented MG-induced inflammation, apoptosis and energy metabolism dysfunction in the chicken lungs and provide basis for new therapeutic targets to control MG infection.
Author Listing: Muhammad Ishfaq;Wei Zhang;Wanying Hu;Syed Waqas Ali Shah;Yuhao Liu;Jian Wang;Zhiyong Wu;Ijaz Ahmad;Jichang Li
Volume: 12
Pages: 3075 - 3089
DOI: 10.2147/IDR.S223085
Language: English
Journal: Infection and Drug Resistance

Infection and Drug Resistance

INFECT DRUG RESIST

影响因子:2.9 是否综述期刊:否 是否OA:是 是否预警:不在预警名单内 发行时间:- ISSN:1178-6973 发刊频率:- 收录数据库:SCIE/Scopus收录/DOAJ开放期刊 出版国家/地区:UNITED STATES 出版社:Dove Medical Press Ltd.

期刊介绍

About Journal Editors Peer Reviewers Articles Article Publishing Charges Aims and Scope Call For PapersISSN: 1178-6973Editor-in-Chief: Professor Suresh AntonyAn international, peer-reviewed, open access journal that focuses on the optimal treatment of infection (bacterial, fungal and viral) and the development and institution of preventative strategies to minimize the development and spread of resistance.

关于期刊编辑同行评审文章文章出版收费目标和范围呼吁论文ISSN:1178- 6973主编:Suresh Antony教授一本国际性、同行评审、开放获取的期刊,重点关注感染(细菌、真菌和病毒)的最佳治疗以及预防策略的开发和制度,以尽量减少耐药性的发展和传播。

年发文量 682
国人发稿量 466
国人发文占比 68.33%
自引率 6.9%
平均录取率 -
平均审稿周期 16 Weeks
版面费 US$2836
偏重研究方向 Medicine-Pharmacology (medical)
期刊官网 https://www.dovepress.com/infection-and-drug-resistance-journal
投稿链接 https://www.dovepress.com/submit_step_1.php

质量指标占比

研究类文章占比 OA被引用占比 撤稿占比 出版后修正文章占比
88.12% 98.64% 0.23% 0.68%

相关指数

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期刊预警不是论文评价,更不是否定预警期刊发表的每项成果。《国际期刊预警名单(试行)》旨在提醒科研人员审慎选择成果发表平台、提示出版机构强化期刊质量管理。

预警期刊的识别采用定性与定量相结合的方法。通过专家咨询确立分析维度及评价指标,而后基于指标客观数据产生具体名单。

具体而言,就是通过综合评判期刊载文量、作者国际化程度、拒稿率、论文处理费(APC)、期刊超越指数、自引率、撤稿信息等,找出那些具备风险特征、具有潜在质量问题的学术期刊。最后,依据各刊数据差异,将预警级别分为高、中、低三档,风险指数依次减弱。

《国际期刊预警名单(试行)》确定原则是客观、审慎、开放。期刊分区表团队期待与科研界、学术出版机构一起,夯实科学精神,打造气正风清的学术诚信环境!真诚欢迎各界就预警名单的分析维度、使用方案、值得关切的期刊等提出建议!

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时间 预警情况
2024年02月发布的2024版 不在预警名单中
2023年01月发布的2023版 不在预警名单中
2021年12月发布的2021版 不在预警名单中
2020年12月发布的2020版 不在预警名单中

JCR分区 WOS分区等级:Q2区

版本 按学科 分区
WOS期刊SCI分区
WOS期刊SCI分区是指SCI官方(Web of Science)为每个学科内的期刊按照IF数值排 序,将期刊按照四等分的方法划分的Q1-Q4等级,Q1代表质量最高,即常说的1区期刊。
(2021-2022年最新版)
INFECTIOUS DISEASES Q2
PHARMACOLOGY & PHARMACY Q2

关于2019年中科院分区升级版(试行)

分区表升级版(试行)旨在解决期刊学科体系划分与学科发展以及融合趋势的不相容问题。由于学科交叉在当代科研活动的趋势愈发显著,学科体系构建容易引发争议。为了打破学科体系给期刊评价带来的桎梏,“升级版方案”首先构建了论文层级的主题体系,然后分别计算每篇论文在所属主题的影响力,最后汇总各期刊每篇论文分值,得到“期刊超越指数”,作为分区依据。

分区表升级版(试行)的优势:一是论文层级的主题体系既能体现学科交叉特点,又可以精准揭示期刊载文的多学科性;二是采用“期刊超越指数”替代影响因子指标,解决了影响因子数学性质缺陷对评价结果的干扰。整体而言,分区表升级版(试行)突破了期刊评价中学科体系构建、评价指标选择等瓶颈问题,能够更为全面地揭示学术期刊的影响力,为科研评价“去四唯”提供解决思路。相关研究成果经过国际同行的认可,已经发表在科学计量学领域国际重要期刊。

《2019年中国科学院文献情报中心期刊分区表升级版(试行)》首次将社会科学引文数据库(SSCI)期刊纳入到分区评估中。升级版分区表(试行)设置了包括自然科学和社会科学在内的18个大类学科。基础版和升级版(试行)将过渡共存三年时间,推测在此期间各大高校和科研院所仍可能会以基础版为考核参考标准。 提示:中科院分区官方微信公众号“fenqubiao”仅提供基础版数据查询,暂无升级版数据,请注意区分。

中科院分区 查看说明

版本 大类学科 小类学科 Top期刊 综述期刊
医学
3区
INFECTIOUS DISEASES
传染病学
3区
PHARMACOLOGY & PHARMACY
药学
3区
2021年12月
基础版
医学
3区
INFECTIOUS DISEASES
传染病学
3区
PHARMACOLOGY & PHARMACY
药学
3区
2021年12月
升级版
医学
3区
INFECTIOUS DISEASES
传染病学
3区
PHARMACOLOGY & PHARMACY
药学
3区
2020年12月
旧的升级版
医学
3区
INFECTIOUS DISEASES
传染病学
4区
PHARMACOLOGY & PHARMACY
药学
3区
2022年12月
最新升级版
医学
3区
INFECTIOUS DISEASES
传染病学
3区
PHARMACOLOGY & PHARMACY
药学
3区